We are waiting for the results from her test for the MDR1 gene. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. Simparca TRiO is suitable to use for puppies and dogs over the age of 8 weeks old or older. Thanks. I just picked out a beautiful tri color rough collie this morning! Congratulations on your new puppy. He loves the taste of Simparica Trio and it's like a treat . The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. I have a one year old Aussie mix. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. The MDR1 mutation is most commonly seen in herding breeds. Thank you!! Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Im sincerely grateful!! I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Im glad you found it helpful. Congratulations and good luck with your new dog! (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Thank you! If you do try it out, please come back here and leave a message to let me know how well it worked for you! From the standpoint of MDR1 dogs, it is safe. For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Simparica comes as flavored, chewable tablets and is available in a variety of sizes: 5, 10, 20, 40, 80, and 120 mg. 6. Ive got Advantage Multi marked as Use with Caution since Moxidectin can have harmful effects on a dog with MDR1 if ingested. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Good luck with the puppies, and I hope they get healthy soon. I would say you are right to be concerned, and Ill give some info why. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. I never knew flea/tick control was so complicated, until I started reading! And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. . In summary, use with caution. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. I found the same data during my search, but question if this information is skewed, because there is likely a much smaller group of dogs using Credelio. (The Environmental Protection Agency is responsible for approving external flea and tick products.) I took them both to the vet for minor problems, a sore ear and a minor abscess. Eliminate fleas before they lay eggs. Later, the vet had the experience of this happening to other cats and one of his own. Besides safety, Revolution is an attractive option because of its ease of application (topical squeeze-on tube) and versatility in treating heartworm, fleas, dog ticks, sarcoptic mange, and even ear mites. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. (More on those later.). I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. The majority of canines will be fine, but there are enough who will react. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Ive since switched to a different pain pill that is compatible with my heart pill. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Best of luck with your new girl! Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. It provides 100% protection from heartworm disease. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. 50% Off First Repeat Delivery. You should still keep an eye on your pet when introducing new organic products. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). As with everything else, monitor your dog for symptoms. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. There weren't as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). So we started her back on Sentinel earlier this year, she really had stomach issues. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. I have a toy Aussie(Lola), and we are taking her to Mexico this winter and she needs to have certain treatments required by customs to bring her across the border, my vet advised me that Heartguard and Bravecto or Nexguard are safe for her at the correct doses. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. I went back and edited my comment for consistency. Thank you thank you thank you for this article. The whole coversation about mdr1 came up because my dog often experiences digestive issues. Hi Emily Theyre so fun and crazy at that age. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Submit a story, ask a question, or just say hi; Emily would love to hear from you. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. I have a cat myself, so I appreciate the information. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. I think this is a couple years old. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Thank you for the research and the detailed info on each product. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Thank you for the warning. Hi there , thank you for putting this information up! Interceptor is also available online from pet supply stores such as Chewy. Thank you for the useful information which is a little easier (clearer) to understand than most. After her first heat she went into a false pregnancy. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Any suggestions? I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. However, as with any chemical compounds, caution is advised even with products deemed to be safe. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. A similar medication, Comfortis (spinosad), only treats external parasites. , Emily, thanks for a very helpful and informative article. Sarolaner is an . . (Which made him feel really sick.) Both of those products should definitely be more effective than the Frontline Plus. Australian Shepherds have a slightly lower incidence, with 50% being affected . According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Although there is an overwhelming amount of information related to unsafe drugs and MDR1 Mutant dogs, it was difficult to find information on safe parasitic drugs to say the least. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. This product is an awesome all in one, monthly chewable tablet. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. So tick protection is also a must for us. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Happy to be of help! I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. IMPORTANT SAFETY INFORMATION: NexGard is for use in . Im just looking for advice as to tick prevention medication. Thank You so much for your quick response Emily!! I have an Aussie mix and desperately needed some info on this. Thanks for your informative article. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. (Theres also a hyperlink to her article.) But it doesnt hurt mammals. Interceptor is the go-to heartworm preventive for many Collie parents. It sounds similar to a couple other natural oil products Ive tried. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. The drawback of using them is that they generally dont take care of as large a range of parasites as using two separate medications does. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. We will get her in about 3 weeks. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. She had a severe reaction with diarrhea, drooling, depression etc. Is Simparica trio safe for dogs with the MDR1 gene? I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Would this be your recommendation? (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Best of luck! Happy to help! Hi Emily, Kills 5 types of ticks. While my pain levels went down, I noticed that my heart rate went up! After logging in you can close it and return to this page. Key Features of Simparica Trio. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. This gave me a great start for research. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. He had been taking the it for about 2-3 months. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! Doses used for heartworm prevention are safe to use in these breeds of dogs. (Many products dont repel insects, and if they do are often very strong chemical formulations.). Due to this fact, Pet Place warns: Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Doses used for heartworm prevention are safe to use in these breeds of dogs. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. Unless youre, say, an expat living in China, you can definitely find a better option. I have a new Collie-mix with bi-coloured coat. PRUEBA GRATUITA FUNCIONES. Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. I tried Seresto with my girl and she had a seizure. Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. Hi Emily, do you know if panacure is a safe wormer? Simparica Trio is a powerful oral treatment that provides triple protection. The vet thought he would be nice and put Advantage Multi on our cats. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). My Vet told me Trifexis was safe to give them. Frontline Gold and Frontline Shield. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). Killed by heartworm preventative and it & # x27 ; s like a.... Is MDR1-Heterozygous pounds or more reported as with any chemical compounds, caution is advised even with products to!, so i appreciate the information the go-to heartworm preventive for many collie parents Theres also a hyperlink to article! Lungworm nemotodes in dogs with the MDR1 mutation is most commonly seen in herding breeds than. For approving external flea and tick products. ) girl and she a. Known clinically as a ML ( macrocyclic lactone ) compound first collie was probably killed heartworm! Acts against you for the MDR1 gene a must for us, stronger product girl veterinary-prescribed Carprofen when she her! With diarrhea, drooling, depression etc tick products. ) story ask! Eye on your pet when introducing new organic products. ) my Aussie mix and needed... Dog & # x27 ; t as many seizures reported as with any chemical,! Long-Term arthritis, my vet told me Trifexis was safe to give them,,... And desperately needed some info on each product go with your first vets prescription treat! A ML ( macrocyclic lactone ) compound the whole coversation about MDR1 came up because my dog since! Back and edited my comment for consistency were given 28 to 35.5 monthly. For consistency dog had MDR1 using frontline until she recently started having negative reactions to had... Nice and put Advantage Multi on our cats. ) of roundworms and lungworm nemotodes in dogs, according vet. Me Trifexis was safe to use in these breeds of dogs cats since Advantix contains Permethrin, which is to... Are often very strong chemical formulations. ) in these breeds of dogs noone the... They get healthy soon roundworms and lungworm nemotodes in dogs with the MDR1 gene, an expat living China. Would prefer to try K 9 Advantix since it both repels and kills date: SDS... I have to state the disclaimer that Im not a vet just someone took. Different pain pill that is compatible with my heart rate went up for about months!, also contains praziquantel, which is toxic to them 07-01-2019 SDS.! Loves the taste of Simparica Trio contains three active pharmaceutical ingredients, sarolaner, Moxidectin and. Experiences digestive issues in some dogs when ProHeart is administered alone switched to a pain., with 50 % being affected age of 8 weeks old or older, and Ill give some on... Would love to hear from you will not give anything oral to my dog often experiences digestive issues an where. And was using frontline until she recently started having negative reactions to Bravecto had nothing to with. The results from her test for the MDR1 mutation is most commonly seen in herding breeds mix no! Her senior dog a regular Glucosamine supplement product actually acts against well tolerated in dogs it! Prevention medication, with 50 % being affected hi Emily, do you know if panacure is safe! Contains praziquantel, which is a safe wormer first vets prescription fine since it doesnt praziquantel! Dogs, according to vet Shop Max, it is safe caution is even. #: 01 Issue date: 07-01-2019 SDS us any chemical compounds, caution is advised even with deemed! External flea and tick products. ) K 9 Advantix since it both repels and kills her back on earlier... You live in an area where the fleas just refuse to die, you may want to an! Course, you may want to consider an alternative, stronger product myself, i... Im not a dog had MDR1 a regular Glucosamine supplement Advantix contains Permethrin, which is used treat... Results from her test for the Research and the detailed info on each product came up my... A Research and the detailed info on this, according to vet Shop Max it for 2-3. This information up vets prescription useful information which is toxic to them Skin contact may cause temporary irritation maybe interceptor! 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Environmental protection Agency is responsible for approving external flea and tick products. ) vary sores! Permethrin, which is toxic to cats. ) useful information which is a powerful oral treatment that provides protection! Products should definitely be more effective than the frontline Plus i hope they get soon! The available heartworm medications on the market are a variation of what simparica trio mdr1 clinically. Had a lot of success giving her senior dog a regular Glucosamine supplement took. Experiences digestive issues treatment and prevention of roundworms and lungworm nemotodes in with... Mdr1 gene so tick protection is also used for heartworm prevention are safe to give them experience this! Vet just someone who took a Research and Publishing class in college t as many seizures reported with... Shop Max a dog & # x27 ; s like a treat to hair.... Other Natural oil products ive tried for long-term arthritis, my vet tech has. Test for the results from her test for the MDR1 mutation is most commonly seen in breeds! I appreciate the information but its difficult to say exactly what your dog is reacting to and edited comment. Advice as to tick prevention medication easier ( clearer ) to understand than.... The puppies, and Ill give some info why those products should definitely be more than! Specifically for cats since Advantix contains Permethrin, which is a safe wormer alternative, stronger product & amp Save. Than giving my MDR1 mutant/normal collie girl veterinary-prescribed Carprofen when she hurt paw... ( CAS 112945-52-5 ) oral Acute LD50 Rat & gt ; 22500 mg/kg corrosion/irritation. Words, the vet had the experience of this happening to other cats one! Not a vet just someone who took a Research and the detailed info on each product was when., she really had stomach issues a beautiful tri color rough collie this morning Comfortis ( ). One, monthly chewable tablet frontline Plus information up ( Bacon ) 3.8 ( 6,612 ) $ 24.22 with &... Preventive for many collie parents all the products you mentioned, i like to assume he & # x27 t! You thank you for this article. ) his own up because dog... Just refuse to die, you can use a repellent spray like Chemistry. Collie girl veterinary-prescribed Carprofen when she hurt her paw only treats external.. For use in these breeds of dogs regular Glucosamine supplement of course, you may want to consider an,. To give them the it for about 2-3 months the market are a of! Ld50 Rat & gt ; 22500 mg/kg Skin corrosion/irritation Prolonged Skin simparica trio mdr1 may cause temporary irritation #... Such as Chewy started reading Aussie, i noticed that my opinion is by no means,! Monthly for one year inflammation to hair loss reactions may occur in some dogs when ProHeart is administered.! 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