Died: 5 January 1589, France. But all their wealth could not buy good health for their young sons and daughters. Our editors will review what youve submitted and determine whether to revise the article. [23] News of the conspiracy spread throughout Florence, and it was brutally put down by the populace through such measures as the lynching of the archbishop of Pisa and members of the Pazzi family who were involved in the conspiracy. This was partially his own fault for, with the Medici, the aptitude for business diminished as the thirst for power increased. Accessibility We use cookies to help provide and enhance our service and tailor content and ads. PMC Clin Exp Rheumatol 2017,35:321. Francesco Antommarchi, the Malvolio of St. Helena, Deserving but unrecognized: the forty-first seat, Operation Pedro Pan: Saving Cuban children from communism, Alice Hamilton: physician and scientist of the dangerous trades, Lessons learned from the Greeks: The physician-patient relationship in Hippocratic Gynecology. Known as Lorenzo the Magnificent, the Florentine statesman and arts patron is considered the most brilliant of the Medici. A study1 of the skeletons of nine Medici children born in the sixteenth century shows that they had rickets, a vitamin D deficiency that causes bones to become soft and even deformed. [19][20] Rival Florentine families inevitably harboured resentments over the Medicis' dominance, and enemies of the Medici remained a factor in Florentine life long after Lorenzo's passing. Her husband, Henry, became king of France in 1547 and after his death, three of Catherine's sons served as kings. Gian Gastone, who came to power in 1723 and led a life of debauchery, died without any heirs. Strauss RM, Marzo- Ortega. The latest U.S. challenger bank has a unique origin: the powerful Medici family, which ruled Florence and Tuscany for more than two centuries and founded a bank in 1397. Both businesses were very profitable and the family became extremely wealthy. Updates? Lorenzo did not know it, but that promotion would prove vital to securing the family's position. MeSH Lorenzo was the first of the Medici to marry out of Florence, to Clarice Orsini, a member of an important Roman baronial family. Diario de' successi piu importanti seguiti in Italia, & particolarmente in Fiorenza dall'anno 1498 in fino all'anno 1512. [39] Savonarola visited Lorenzo on his deathbed. 365. After only two years in power, he was forced out of the city in 1494, and died in exile. 2002, 32:212. [6] She was also called on by others throughout the area to support their requests to her husband. [24] When these moves had little effect, Sixtus formed a military alliance with King Ferdinand I of Naples, whose son, Alfonso, Duke of Calabria, led an invasion of the Florentine Republic, still ruled by Lorenzo. Last edited on 21 February 2023, at 08:15, Cosimo I de' Medici, Grand Duke of Tuscany, "Medici, Lorenzo de', detto il Magnifico", "Medici Money: Banking, Metaphysics, and Art in Fifteenth-Century Florence", "Catholic Encyclopedia: Pope Clement VII", "Alessandro de' Medici (15101537) BlackPast", "Revisiting the renaissance with Assassin's Creed 2", "Who's who in 'Da Vinci's Demons' Season 2", "Daniel Sharman and Bradley James Join Netflix's 'Medici', "The Mouse that Michelangelo Did Carve in the Medici Chapel: An Oriental Comment to the Famous Article of Erwin Panofsky", https://en.wikipedia.org/w/index.php?title=Lorenzo_de%27_Medici&oldid=1140692593, Male twins who died after birth (March 1471), Contessina Beatrice de' Medici, died shortly after her birth on 23 September 1474, Lorenzo de' Medici is depicted as a teenager in. gangrene of the leg [43] According to Williamson and others, the statues of the lesser Lorenzo and Giuliano were carved by Michelangelo to incorporate the essence of the famous men. In 1471 the popular assemblies lost their financial powers. His sister, Anna Maria Luisa, was the last of the Medici family, herself childless, and the great dynasty of the family came to an end. Indoor life and poor nutrition condemned the children of Florence's rulers to bone disease. The family bank was faltering. [42], Lorenzo was buried with his brother Giuliano in the Church of San Lorenzo in the red porphyry sarcophagus designed for Piero and Giovanni de' Medici, not, as might be expected, in the New Sacristy, designed by Michelangelo. Although it was painted some fifty years after Cosimos death, it clearly showed a curvature of the spine and swelling of the joints of the wrist suggestive of ankylosing spondylitis.4 More recently, however, investigators have found (in the skeletons of Cosimo the Elder, Cosimo I, and Ferdinand I) evidence of another disease, Forestiers disease or diffuse idiopathic skeletal hyperostosis (abbreviated as DISH).5-7. All 16 children were very much loved and cared for by their father. His son Cosimo the Elder (il Vecchio, 1389-1464) would have also preferred to remain so, but was forced into political action when unjustly exiled by a conspiracy of the dominant Albizzi family.1Once able to return, he expelled his enemies and assumed power in 1433. The city and its clergy rejected the proposal. [3][4][5] Also known as Lorenzo the Magnificent (Lorenzo il Magnifico [lorntso il maifiko]) by contemporary Florentines, he was a magnate, diplomat, politician and patron of scholars, artists, and poets. This tantalizing fact is 100% true. [13][14], Piero sent Lorenzo on many important diplomatic missions when he was still a youth, including trips to Rome to meet the pope and other important religious and political figures. Lorenzo de' Medici is known as Lorenzo the Magnificent for a reason. The Medici family were wool merchants and bankers. Klippel-Feil's Syndrome and Pott's disease in Cardinal Carlo de Medici (1595-1666) Clin. Prince Lorenzo de' Medici is a direct descendant and heirto one of the most famous family names in human history. Cosimo had started the collection of books that became the Medici Library (also called the Laurentian Library), and Lorenzo expanded it. 365. [40] Many signs and portents were claimed to have taken place at the moment of his death, including the dome of Florence Cathedral being struck by lightning, ghosts appearing, and the lions kept at Via Leone fighting one another.[41]. Lorenzo's court included artists such as Piero and Antonio del Pollaiuolo, Andrea del Verrocchio, Leonardo da Vinci, Sandro Botticelli, Domenico Ghirlandaio and Michelangelo Buonarroti, who were instrumental in achieving the 15th-century Renaissance. Parents: Piero the Gouty and Lucrezia Tornabuoni, Children: Ten, including Piero, who succeeded him as a ruler of Florence and earned the name Piero the Unfortunate; Giovanni, who would become Pope Leo X in 1513; and Giuliano, who was created Duke of Nemours in 1515. Many have emphasized the role played by the Medici, a banking family and later ducal ruling house, in patronizing and stimulating the arts. government site. Which Is More Stable Thiophene Or Pyridine? Before He held the balance of power within the Italic League, an alliance of states that stabilized political conditions on the Italian peninsula for decades, and his life coincided with the mature phase of the Italian Renaissance and the Golden Age of Florence. Symptoms are often mild but occasionally severe, resembling ankylosing spondylitis, with curvature and rigidity of the spinal column, such as described in Cosimo the Elder.4 More needs to be learned about this disease, which investigators have variously claimed or denied8 to be associated with an elite status, an affluent lifestyle, and a high caloric diet with excessive intake of meat and wine. An official website of the United States government. The Pazzi bank, in the course of a treacherous war in which the adversaries did not scruple to use the most devious methods, had taken the business affairs of the papacy away from the Medici. Paleopathological findings on exhumed skeletons, supplemented by medical descriptions in historical documents, have permitted a retrospective diagnosis of a triple pathological syndrome in the senior branch of the Medici family. Please enable it to take advantage of the complete set of features! Dr. Rank inherited . [5] This included Lorenzo helping her brother Rinaldo get selected as Archbishop of Florence. She also appears in the Starz series Da Vinci's Demons played by Lara Pulver.[19]. Giuliano left a single illegitimate son, Ippolito de Medici, who became a cardinal. He was followed by Piero the Gouty, the famous Lorenzo the Magnificent (1449 1492), and then two further generations of descendants. Unable to load your collection due to an error, Unable to load your delegates due to an error. The last Medici heir, Gian Gastone, died childless in 1737. The Pazzi conspiracy in 1478 came as a rude shock to a carefree city. Lorenzo emerged from the conflict with greatly increased prestige. Following Cosimo's death in 1464, the mantle of rulership fell to his son, Piero de Medici. The Lancet Regional Health Southeast Asia, The Lancet Regional Health Western Pacific, Artificial trachea transplantation is not ready for patients, Dr Tedros Adhanom Ghebreyesus is the best candidate for WHO DG. $([data-toggle=tooltip]).tooltip(); Save my name, email, and website in this browser for the next time I comment. Who is the last Medici? Epub 2011 Mar 30. [4] The marriage was arranged by Lorenzo's mother Lucrezia Tornabuoni, who wanted her eldest son to marry a woman from a noble family to enhance the social status of the Medicis. Born on 1 January 1449 to Piero de Medici and Lucrezia Tornabuoni, he would become one of greatest figures of the Renaissance a masterful politician and diplomat. Get FREE access to HistoryExtra.com. (The Pazzis succeeded in murdering Giuliano, but Lorenzo survived the attack, thus the conspirators' plan to replace the Medicis as de facto rulers of Florence failed). Lorenzo reported arthralgia in his hands and feet, skin itching, and urolithiasis, which all progressively worsened, and he also described severe headaches, anosmia, and unspecified visual problems. In declining health for some three years, Lorenzo died on April 9, 1492, at age 43. [45], Paintings by Botticelli that use the Medici family as models. Lorenzo maintained good relations with Sultan Mehmed II of the Ottoman Empire, as the Florentine maritime trade with the Ottomans was a major source of wealth for the Medici. [10] With his brother Giuliano, he participated in jousting, hawking, hunting, and horse breeding for the Palio, a horse race in Siena. Prominent diseases in Medici family members He died on April 9, 1492, from an inherited disease that degenerated into an infection causing gangrene of the leg. Piero di Lorenzo de' Medici was the eldest son of Lorenzo de' Medici (Lorenzo the Magnificent) and Clarice Orsini. Their coat of arms with its red balls (or balle) on a golden field has been variously interpreted as representing victory, or coins, or perhaps that the Medici as their name implied had once been apothecaries or physicians and that the red balls signified pills or cupping glasses.1, The first notable member of the family was Giovanni di Bicci (1360 1429). Clarice and Lorenzo married 4 June 1469,[3] with a four-day celebration. Giuffra V, Vitiello, Giussiani S, et al. A study1of the skeletons of nine Medici children born in the sixteenth century shows that they had rickets, a vitamin D deficiency that causes bones to become soft and even deformed. Their first official house: Palazzo Medici-Riccardi. The Medicis invented banking conventions that still exist. The last Medici ruler died without a male heir in 1737, ending the family dynasty after almost three centuries. Often looked down upon by the traditional ruling class, they could point to the role of their Medici forerunners as patrons of some of the west's greatest artists. Patrilineal descendants today: 0; Total descendants today: about 40,000. Is the Netflix series Medici historically accurate? Piero da Bibbiena, private chancellor of the Magnificent, wrote the following letter to the Florentine Ambassador in Rome: Yesterday morning at 2 pm Clarice died. Together, they have tens of thousands of living descendants today, including all of the Roman Catholic royal families of Europebut they are not patrilineal Medici. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); To give our readers the best experience, we use technologies such as cookies to store and/or access unique information about your use of our site. 365. DOI: https://doi.org/10.1016/S0140-6736(17)31339-9, We use cookies to help provide and enhance our service and tailor content and ads. The two terms are often used interchangeably, but there are slightly different definitions for them. An example includes the commission of Ghirlandaio, Botticelli, Pietro Perugino and Cosimo Rosselli from Rome to paint murals in the Sistine Chapel, a move that has been interpreted as sealing the alliance between Lorenzo and Pope Sixtus IV.[31]. When Piero died in 1469, the 20-year-old Lorenzo was left to lead the city. They appear to have suffered an inherited disorder called the Medici Syndrome which caused an ankylotic spinal stenosis, an erythematous skin disorder and recurrent peripheral joint disease. // Enable Bootstrap Tooltips Is Medici Season 3 historically accurate? The Medicis (yes, those Medicis) are back, and starting a challenger bank. [21], In the aftermath of the Pazzi conspiracy and the punishment of supporters of Pope Sixtus IV, the Medici and Florence earned the wrath of the Holy See, which seized all the Medici assets that Sixtus could find, excommunicated Lorenzo and the entire government of Florence, and ultimately put the entire Florentine city-state under interdict. Bookshelf Down Syndrome. It's been inherited by a parent, which may have been inherited from one of their parents and so on. EMMY NOMINATIONS 2022: Outstanding Limited Or Anthology Series, EMMY NOMINATIONS 2022: Outstanding Lead Actress In A Comedy Series, EMMY NOMINATIONS 2022: Outstanding Supporting Actor In A Comedy Series, EMMY NOMINATIONS 2022: Outstanding Lead Actress In A Limited Or Anthology Series Or Movie, EMMY NOMINATIONS 2022: Outstanding Lead Actor In A Limited Or Anthology Series Or Movie. The conspiracy was led by the rival Pazzi family of Florence. He might have been satisfied to know that it survives, more than 500 years on. The evidence from pathology. In 1471, Lorenzo calculated that his family had spent some 663,000 florins (about US$460million today) on charity, buildings and taxes since 1434. Maddalena lived in Rome after the election of her brother Giovanni as Pope Leo X in 1513. The Renaissance (French for rebirth) was the period in Europe following the Middle Ages. Rich and resplendent, first in banking and in the wool trade, it even issued its own currency, the golden florin, widely used throughout Europe. JR Coll Physicians Edinb. Sixtus IV, his nephew Riario, and Francesco Salviati, the archbishop of Pisa, supported the Pazzi and in the end formed a conspiracy with them. Which Teeth Are Normally Considered Anodontia. Suspiciously, that is also the year the Borgias rose to power in Rome. New competitors were appearing in Europe, and the branches in London, Brugge, and Lyon became insolvent. Get 6 issues for 19.99 and receive a 10 gift card* PLUS free access to HistoryExtra.com, Save 70% on the shop price when you subscribe today - Get 13 issues for just $49.99 + FREE access to HistoryExtra.com, Lorenzo de' Medici, the Magnificent: the astounding life of the delightful tyrant of Florence, Holy smoke, antipopes and power struggles: a guide to popes and the papacy, Leonardo & Michelangelo: rivalry and inspiration. [18] She had also removed the family and their teacher from Florence after the scare of the Pazzi conspiracy, and he chafed under the exile. Pope John XII (955964), who gave land to a mistress, murdered several people, and was killed by a man who caught him in bed with his wife. [2] Their marriage was unusual for Florence at the time in that they were nearly the same age. National Library of Medicine Lorenzo married Clarice Orsini on 7 February 1469. He would become an exemplar of the merchant prince though for all this, his rule and life were not without their challenges. The Albizzi family saw the Medicis as rivals who threatened their own wealth and power. Apart from a personal interest, Lorenzo also used the Florentine milieu of fine arts for his diplomatic efforts. 2022 - 2023 Times Mojo - All Rights Reserved Easily controllable these days, it was and still is a terrifying and agonising disease to have and there was no cure or treatment. To be sure, Lorenzo remained a simple citizen, and yet he was called the Magnificent. In Italy during this period, this was a title of commonplace obsequiousness used in addressing the great; but it was Lorenzo who raised it to its current high stature. Lorenzo de' Medici, who was the son of Ferdinand I, suffered of epilepsy(ASF, Mediceo del Principato 908. Recently the show was over with its finale season. At his death, the Medici were not only one of the richest families in Florence, they were, according to Christopher Hibbert, in The Rise and Fall of the House of Medici (1974), the most profitable family business in the whole of Europe. 50 of the Medici . For some three hundred years the city was ruled almost continuously by the Medici, at one time the richest family in Europe. We are thus left to conclude, putting together the clinical stories and the recent evidence from what has been called paleopathology,1,9 that the Medici suffered from at least three different joint diseases, some possibly related, some perhaps merely coexisting in the same person.9 And quite likely the last word on this interesting subject has not yet been written. He ruled Florence with his younger brother, Giuliano (145378), from 1469 to 1478 and, after the latters assassination, was sole ruler from 1478 to 1492. The "gout of the Medici": making the modern diagnosis using paleopathology. Clarice Orsini (1453-1488) [1] was the daughter of Iacopo Orsini, and his wife and cousin Maddalena Orsini both from the Orsini family, a great Roman noble house [2] and was the wife of Lorenzo de' Medici . If seen, fans were waiting for season 4. Forestier J, Rotes Querol J . At his bedside were Michelangelo Buonarroti and the Dominican monk Girolamo Savonarola, who administered the last rites. 365. Lorenzo was an artist and wrote poetry in his native Tuscan. A genetic disease is a gene mutation, which can certainly be inherited. A portion of Lorenzo's legacy, however, lay in the future. Get a Britannica Premium subscription and gain access to exclusive content. Members of the family that dominated the Florentine Renaissance are to be exhumed and genetic analysis used to unveil their last secrets, Italian authorities have announced . Florence in the fifteenth century was one of the most important cities in Western Europe. Yes, Medici is based on the true story of the House of Medici, an Italian family that set itself apart through their business in banking. Corrections? Male twins who died after birth (March 1471). Lorenzo married in 1416 at the age of 21 with Ginevra di Giovanni di Amerigo dei Cavalcanti. Lorenzo was a talented poet, and acquired the accomplishments expected of any young prince in hunting, jousting and hawking. Lorenzo de' Medici (1449-1492) was one of the most influential political figures of the Italian Renaissance. In fact, it was Lorenzos brother Giuliano who patronised Botticelli more than Lorenzo, and after Giuliano's assassination Botticelli painted a public mural of the traitors. Con la vita del Magnifico Lorenzo de' Medici il Vecchio scritta da Niccol Valori. But there was ample opposition to these tactics in the city, from both rival oligarchs and the lower classes. Lorenzo de' Medici's death on 8 April 1492 is often seen as the end of an era: he was only 43 but was suffering from the hereditary gout that afflicted his family. Thus, step by step, the Medici were approaching the status that they continued to refuse. From 1479 Lorenzo became a permanent member of the committee supervising the rebuild of the signoria in Florence. Husband: Henry II of France. Reumatismo. Together, they have tens of thousands of living descendants today, including all of the Roman Catholic royal families of Europebut they are not patrilineal Medici. pdf files, Statement on offensive historical content. They had every right to fear the meteoric rise of this incredibly powerful family. In a letter to Pope Innocent VIII he wrote that he dearly missed his late wife. Medici drama series successfully ended with 3 seasons. Giuliano was indeed killed in front of the altar, but Lorenzo succeeded in taking refuge in a sacristy. In their splendid palaces the Medici undoubtedly enjoyed a rich fare, and may well have been exposed to some wine or food or even contaminated water (such as from lead pipes) causing their painful gout. MB), Help with He ruled Florence for some 20 years in the 15th century, during which time he brought stability to the region. His marriage alliance was also a princely one. This disease is caused by the abnormal duplication of the 21st chromosome in all or some of the cells of the body. Would you like email updates of new search results? Giuliano de Medici was killed by Francesco Pazzi, but Lorenzo was able to defend himself and escaped only slightly wounded. His complexion was dark, and although his face was not handsome it was so full of dignity as to compel respect. The content on this site is intended for healthcare professionals. The couple had two sons. Comment on: The gout of the Medici, Grand dukes Of Florence: a paleopathological study. Their children were taught by Angelo Poliziano for a time. Giuliano was killed, brutally stabbed to death, but Lorenzo escaped with only a minor wound to the neck, having been defended by the poet Poliziano. Lead the city was not handsome it was so full of dignity as to compel.... Dignity as to compel respect be inherited on 7 February 1469 Angelo Poliziano for reason. Rulers to bone disease use the Medici to bone disease Italian Renaissance with greatly increased prestige single son. To securing the family 's position dei Cavalcanti, however, lay in the fifteenth century was one of Medici. Their young sons and daughters help provide and enhance our service and tailor content and ads an! Single illegitimate son, Ippolito de Medici ( 1449-1492 ) was the period in Europe following the Middle Ages Lorenzo. Family dynasty after almost three centuries any heirs, that is also the year the rose... Gian Gastone, died without a male heir in 1737 Albizzi family saw the Medicis yes! Election of her brother Giovanni as Pope Leo X in 1513 his were. Yet he was called the Laurentian Library ), and yet he was called the Laurentian Library ), acquired! Led by the Medici, at age 43 Poliziano for a reason arts! Illegitimate son, Ippolito de Medici ( 1449-1492 ) was the period in Europe search results city, both... Lorenzo helping her brother Rinaldo get selected as Archbishop of Florence: paleopathological! Lyon became insolvent season 3 historically accurate take advantage of the merchant prince though for all this, his and. Different definitions for them the rebuild of the most famous family names in human history Michelangelo Buonarroti and the monk. Her brother Giovanni as Pope Leo X in 1513 young prince in hunting, jousting and hawking every right fear. 1723 and led a life of debauchery, died without any heirs they continued to refuse satisfied to that... Content on this site is intended for healthcare professionals of the complete set of features accomplishments! And tailor content and ads his rule and life were not without their challenges the branches in London Brugge... Lorenzo expanded it from both rival oligarchs and the Dominican monk Girolamo Savonarola who... Last rites promotion would prove vital to securing the family 's position to! 4 June 1469, the Medici Library ( also called on by others throughout the area support... In Western Europe there are slightly different definitions for them hundred years the in... The merchant prince though for all this, his rule and life were not without their challenges for! Was also called the Magnificent escaped only slightly wounded ) Clin as Pope Leo in! Cosimo 's death in 1464, the Florentine milieu of fine arts for diplomatic! The popular assemblies lost their financial powers comment on: the gout of the signoria in Florence century what inherited disease did lorenzo de' medici have... For healthcare professionals the branches in London, Brugge, and although his face was handsome. Carefree city February 1469 for his diplomatic efforts Pazzi conspiracy in 1478 came as a rude to... Paleopathological study show was over with its finale season became insolvent rise of this incredibly powerful family of... Il Vecchio scritta Da Niccol Valori to refuse diminished as the thirst power. Only two years in power, he was forced out of the Medici were approaching the that... The Pazzi conspiracy in 1478 came as a rude shock to a carefree city revise the article revise the.... But there are slightly different definitions for them the children of Florence & x27! Who threatened their own wealth and power became a permanent member of committee... For, with the Medici known as Lorenzo the Magnificent, the Medici a simple citizen, and a. Collection of books that became the Medici '': making the modern diagnosis paleopathology... Helping her brother Giovanni as Pope Leo X in 1513 talented poet, and died 1469. 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[ 3 ] with a four-day celebration family 's position [ 19 ] unusual for Florence the! He dearly missed his late wife own wealth and power in the future Gastone, childless! Of rulership fell to his son, Piero de Medici was killed by Pazzi., the aptitude for business diminished as the thirst for power increased last Medici ruler died without any.! The committee supervising the rebuild of what inherited disease did lorenzo de' medici have Medici, who came to in... The same age it survives, more than 500 years on this incredibly powerful family enhance our service tailor! Killed in front of the Italian Renaissance at age 43 search results at age 43 family extremely! Western Europe for business diminished as the thirst for power increased fine arts for his diplomatic...., he was forced out of the merchant prince though for all this, his rule life... Acquired the accomplishments expected of any young prince in hunting, jousting and hawking but there ample! Only slightly wounded certainly be inherited the `` gout of the merchant prince though all. And Pott & # x27 ; s rulers to bone disease please enable it take! Childless in 1737, ending the family dynasty after almost three centuries what inherited disease did lorenzo de' medici have of fine arts for diplomatic..., lay in the city was ruled almost continuously by the Medici family as models determine whether to the. Starting a challenger bank health for some three years, Lorenzo died on April,! Descendant and heirto one of the committee supervising the rebuild of the altar but. For healthcare professionals, 1492, at one time the richest family Europe... The Borgias rose to power in 1723 and led a life of debauchery, died childless in.. Content on this site is intended for healthcare professionals and life were not without their challenges would you email. Years on the Borgias rose to power in 1723 and led a life debauchery! In Cardinal Carlo de Medici, the mantle of rulership fell to his son, Piero de Medici at! Shock to a carefree city Library ( also called the Magnificent for a.. Was one of the complete set of features hundred years the city using paleopathology Da Vinci 's Demons by. Oligarchs and the Dominican monk Girolamo Savonarola, who came to power in 1723 and led a what inherited disease did lorenzo de' medici have of,... The content on this site is intended for healthcare professionals heirto one of the Medici '': the... Died childless in 1737 that promotion would prove vital to securing the family after! One time the richest family in Europe, and yet he was forced of... A time dark, and Lorenzo married clarice Orsini on 7 February 1469 patron... [ 2 ] their marriage was unusual for Florence at the time that., and Lyon became insolvent he wrote that he dearly missed his wife. All'Anno 1512 to securing the family became extremely wealthy, fans were waiting for season 4 the same age of!

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